313 top medical experts on TDP-43 Proteinopathies across 25 countries and 28 U.S. states, including 176 MDs (Physicians). This is based on an objective analysis of their Scientific Publications, Clinical Trials, Medicare, and NIH Grants.

  1. TDP-43 Proteinopathies: Diseases characterized by the presence of abnormally phosphorylated, ubiquitinated, and cleaved DNA-binding protein TDP-43 in affected brain and spinal cord. Inclusions of the pathologic protein in neurons and glia, without the presence of amyloid, is the major feature of these conditions, thus making these proteinopathies distinct from most other neurogenerative disorders in which protein misfolding leads to brain amyloidosis. Both frontotemporal lobar degeneration and amyotrophic lateral sclerosis exhibit this common method of pathogenesis and thus they may represent two extremes of a continuous clinicopathological spectrum of one disease.
  2. Clinical guidelines are the recommended starting point to understand initial steps and current protocols in any disease or procedure:
  3. Broader Categories (#Experts): Neurodegenerative Diseases (2,937), Proteostasis Deficiencies (1,784) and Narrower Categories: Amyotrophic Lateral Sclerosis (4,992), Frontotemporal Lobar Degeneration (1,494).
  4. Clinical Trials ClinicalTrials.gov : at least 3 including 1 Active, 2 Completed


  

        

                    


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