354 top medical experts on Leigh Disease across 48 countries and 29 U.S. states, including 172 MDs (Physicians). This is based on an objective analysis of their Scientific Publications, Clinical Trials, Medicare, and NIH Grants.

  1. Leigh Disease: A group of metabolic disorders primarily of infancy characterized by the subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, dysphagia, and lactic acidosis. Pathological features include spongy degeneration of the neuropile of the basal ganglia, thalamus, brain stem, and spinal cord. Patterns of inheritance include X-linked recessive, autosomal recessive, and mitochondrial. Leigh disease has been associated with mutations in genes for the pyruvate dehydrogenase complex; cytochrome-C oxidase; ATP synthase subunit 6; and subunits of mitochondrial complex I. (From Menkes, Textbook of Child Neurology, 5th ed, p850).
  2. Clinical guidelines are the recommended starting point to understand initial steps and current protocols in any disease or procedure:
  3. Broader Categories (#Experts): Mitochondrial Diseases (3,186), Inborn Errors Pyruvate Metabolism (334), Inborn Metabolic Brain Diseases (1,358).
  4. Clinical Trials ClinicalTrials.gov : at least 12 including 1 Active, 3 Completed, 5 Recruiting
  5. Synonyms: Subacute Necrotizing Encephalomyelitis,  Subacute Necrotizing Encephalopathy


  

        

                    


    Computing Expert Listing ...

);