898 top medical experts on Down Syndrome across 61 countries and 43 U.S. states, including 819 MDs (Physicians). This is based on an objective analysis of their Scientific Publications, Clinical Trials, Medicare, and NIH Grants.
- Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe intellectual disability. Cardiac and gastrointestinal malformations, a marked increase in the incidence of leukemia, and the early onset of alzheimer disease are also associated with this condition. Pathologic features include the development of neurofibrillary tangles in neurons and the deposition of amyloid beta-protein, similar to the pathology of alzheimer disease. (Menkes, Textbook of Child Neurology, 5th ed, p213)
- Clinical guidelines are the recommended starting point to understand initial steps and current protocols in any disease or procedure:
- Broader Categories (#Experts): Intellectual Disability (5,155), Chromosome Disorders (2,206), Multiple Abnormalities (3,208).
- Clinical Trials : at least 273 including 15 Active, 150 Completed, 54 Recruiting
- Synonyms: Mongolism, Trisomy 21
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