207 top medical experts on Progressive Osseous Heteroplasia across 22 countries and 14 U.S. states, including 55 MDs (Physicians). This is based on an objective analysis of their Scientific Publications, Clinical Trials, Medicare, and NIH Grants.

  1. Progressive Osseous Heteroplasia: Progressive osseous heteroplasia (POH) is a rare genetic bone disorder characterized clinically by progressive extraskeletal bone formation presenting in early life with cutaneous ossification, that progressively involves subcutaneous and then subsequently deep connective tissues, including muscle and fascia. POH overlaps with a number of related genetic disorders including Albright hereditary osteodystrophy, pseudohypoparathyroidism (see these terms), and primary osteoma cutis, that share the common features of superficial heterotopic ossification in association with inactivating mutations of GNAS gene (20q13.2-q13.3), coding for guanine nucleotide-binding proteins. POH can, however, be distinguished clinically by the deep and progressive nature of the heterotopic bone formation.
  2. Clinical guidelines are the recommended starting point to understand initial steps and current protocols in any disease or procedure:
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  • Synonyms: Cutaneous Ossification,  Familial Ectopic Ossification,  Osteodermia,  Osteoma Cutis,  Osteosis Cutis


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