133 top medical experts on Primary hyperoxaluria type 2 across 18 countries and 7 U.S. states, including 19 MDs (Physicians). This is based on an objective analysis of their Scientific Publications, Clinical Trials, Medicare, and NIH Grants.

  1. Primary hyperoxaluria type 2: Primary hyperoxaluria type 2 is a rare condition characterized by the overproduction of a substance called oxalate (also called oxalic acid). In the kidneys, the excess oxalate combines with calcium to form calcium oxalate, a hard compound that is the main component of kidney stones. Deposits of calcium oxalate can lead to kidney damage, kidney failure, and injury to other organs . Primary hyperoxaluria type 2 is caused by the shortage (deficiency) of an enzyme called glyoxylate reductase/hydroxypyruvate reductase (GRHPR) that normally prevents the buildup of oxalate. This enzyme shortage is caused by mutations in the GRHPR gene . Primary hyperoxaluria type 2 is inherited in an autosomal recessive pattern.
  2. Clinical guidelines are the recommended starting point to understand initial steps and current protocols in any disease or procedure:
  3. Support Organizations
  4. Synonyms: D-glycerate dehydrogenase deficiency,  Glyceric aciduria,  Glyoxylate reductase-hydroxypyruvate reductase deficiency,  Type II Primary Hyperoxaluria,  Oxalosis 2,  Oxalosis II


  

        

                    


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