288 top medical experts on Machado-Joseph Disease across 32 countries and 24 U.S. states, including 112 MDs (Physicians). This is based on an objective analysis of their Scientific Publications, Clinical Trials, Medicare, and NIH Grants.

  1. Machado-Joseph Disease: A dominantly-inherited ataxia first described in people of Azorean and Portuguese descent, and subsequently identified in Brazil, Japan, China, and Australia. This disorder is classified as one of the spinocerebellar ataxias (Type 3) and has been associated with a mutation of the MJD1 gene on chromosome 14. Clinical features include progressive ataxia, dysarthria, postural instability, nystagmus, eyelid retraction, and facial fasciculations. dystonia is prominent in younger patients (referred to as Type I Machado-Joseph Disease). Type II features ataxia and ocular signs; Type III features muscular atrophy and a sensorimotor neuropathy; and Type IV features extrapyramidal signs combined with a sensorimotor neuropathy. (From Clin Neurosci 1995;3(1):17-22; Ann Neurol 1998 Mar;43(3):288-96)
  2. Clinical guidelines are the recommended starting point to understand initial steps and current protocols in any disease or procedure:
  3. Broader Categories (#Experts): Spinocerebellar Ataxias (1,752).
  4. Clinical Trials ClinicalTrials.gov : at least 26 including 3 Active, 9 Completed, 8 Recruiting
  5. Synonyms: Azorean Disease,  Joseph Disease,  Spinocerebellar Ataxia Type 3,  Autosomal Dominant Striatonigral Degeneration


  

        

                    


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