388 top medical experts on DNA Damage across 63 countries and 41 U.S. states, including 305 MDs (Physicians). This is based on an objective analysis of their Scientific Publications, Clinical Trials, Medicare, and NIH Grants.
- DNA Damage: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a mutation or a block of DNA replication. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (pyrimidine dimers) or interstrand crosslinking. Damage can often be repaired (DNA repair). If the damage is extensive, it can induce apoptosis.
- Clinical guidelines are the recommended starting point to understand initial steps and current protocols in any disease or procedure:
- Narrower categories (#Experts): DNA Breaks (582), Necrotic DNA Degradation (125).
- Synonyms: DNA Injury, Genotoxic Stress, Genotoxic Stress
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