5 top medical experts on Alexanders leukodystrophy across 1 countries, including 1 MDs (Physicians). This is based on an objective analysis of their Scientific Publications, Clinical Trials, Medicare, and NIH Grants.

  1. Alexanders leukodystrophy: Alexander disease is a type of leukodystrophy characterized by the destruction of the myelin sheath (the fatty covering that acts as an insulator around nerve fiber) and abnormal protein deposits known as Rosenthal fibers. Most cases of Alexander disease begin before age 2 years (the infantile form). Symptoms of the infantile form include an enlarged brain and head, seizures , stiffness in the arms and/or legs, intellectual disability , and delayed physical development. Less frequently, onset occurs later in childhood (the juvenile form) or adulthood. Common problems in juvenile and adult forms of Alexander disease include speech abnormalities, swallowing difficulties, and poor coordination.Alexander disease is caused by mutations in the GFAP gene . While this condition is inherited in an autosomal dominant fashion, most cases result from new mutations in the gene.
  2. Clinical guidelines are the recommended starting point to understand initial steps and current protocols in any disease or procedure:
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